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Submitted: 15 Jan 2020
Accepted: 02 Jun 2020
ePublished: 30 Jun 2020
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Int Electron J Med. 2020;9(2): 86-91.
doi: 10.34172/iejm.2020.15
  Abstract View: 81
  PDF Download: 54

Review Article

Manifestly Altered MicroRNAs in Poly Cystic Ovary Syndrome

Mahta Moraghebi 1 ORCID logo, Milad Rafat 1 ORCID logo, Pegah Mousavi 2 ORCID logo, Kianoosh Malekzadeh 2 * ORCID logo

1 Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
2 Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
*Correspondence to Kianoosh Malekzadeh, Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Mobile: (+98)9176108396 Email: keyanoosh@gmail.com

Abstract

MicroRNAs (miRNAs) constitute a large family of small non-coding RNAs which regulate gene expression at the surface following transcription. They are widely involved in many physiological and pathological processes including polycystic ovarian syndrome (PCOS). PCOS is an endocrine disorder in women. Currently, there is no comprehensive information about the role of miRNAs in PCOS. Thus, this paper has attempted to collate studies on miRNAs in order to determine important changes in their miRNA expression profile in the total blood, serum, plasma, follicular fluid, and granulosa cells in PCOS patients alongside the genes which are targeted for regulation by these miRNAs. This study presents a new approach for using miRNAs and their target genes for diagnosing and treating PCOS.
Keywords: MicroRNA, Small non-coding RNA, Polycystic ovary cancer
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