Volume 8, Issue 1 (6-2019)                   IEJM 2019, 8(1): 31-36 | Back to browse issues page

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Askaripour M, Jamshidian J, Fatemi Tabatabaei S R. The Effect of Galantamine on Liver Function in Hepatic Ischemia/Reperfusion Injury in Rats. IEJM. 2019; 8 (1) :31-36
URL: http://iejm.hums.ac.ir/article-1-167-en.html
Department of Basic Sciences, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Abstract:   (287 Views)
Background: Hepatic ischemia-reperfusion (IR) injury may affect different biological and functional roles of the liver. The present study aims to evaluate the effects of galantamine as a cholinergic agent on the acute and late phases of IR. Materials and Methods: Forty rats were randomly allocated to eight groups (n=5): IR groups were subjected to 90 min ischemia followed by 4 and 24 hours reperfusion to induce acute and late phases of IR, respectively, two groups received pre- or post-treatment dose(s) of galantamine in the acute phase of IR, two groups received pre- or post-treatment dose(s) of galantamine in late phase of IR, and two sham-operated groups. Blood samples were taken, and ALT, AST, ALP, and LDH were measured to evaluate the liver function. Results: Pre-ischemic treatment with galantamine decreased the levels of ALT, AST, and ALP in the acute phase of IR, unlike the late phase (P-value<0.05). Post-ischemic treatment with galantamine in the acute phase of IR was decreased all enzymes (P-value<0.05). Unlike the latter, treatment with galantamine in the late phase of IR was increased these values. Conclusions: We concluded that pre- and post-ischemic treatment with galantamine could be ameliorated hepatic IR injury, in the acute phase versus the late phase, which should be further studied in detail.
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Type of Study: Original Article | Subject: General
Received: 2019/01/20 | Accepted: 2019/03/29 | Published: 2019/06/15

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